Posters & Abstracts

NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly-Informed Integrated Immunotherapy Combining Innate High-Affinity Natural Killer (haNK) Cell Therapy with Adenoviral & Yeast-based Vaccines and Immune Checkpoint Inhibitor to Induce T-Cell Responses in Subjects with TNBC Who Have Progressed on or after Standard-of-Care Therapy

NANT Cancer Vaccine (NCV): An Orchestration of Immunogenic Cell Death by Overcoming Immune Suppression and Activating Natural Killer (NK) and T Cell Therapy in Patients with Greater than 3rd Line Metastatic Pancreatic Cancer
Tara Seery, Arvind Shinde, Mira Kistler, Lennie Sender, Anand Annamalai, Omid Jafari, Frank Jones, John H. Lee, Patrick Soon-Shiong
Jan 2019

NANT Cancer Vaccine (NCV): An Orchestration of Immunogenic Cell Death by Overcoming Immune Suppression and Activating Natural Killer (NK) and T Cell Therapy in Patients with Greater Than 3rd-Line Triple-Negative Breast Cancer (TNBC) or Head and Neck Squamous Cell Carcinoma (HNSCC)
Chaitali Nangia, Mira Kistler, Lennie Sender, John H. Lee, Frank Jones, Patrick Soon-Shiong
Nov 2018

NANT Cancer Vaccine (NCV): An Orchestration of Immunogenic Cell Death by Overcoming Immune Suppression and Activating Natural Killer (NK) and T Cell Therapy in Patients with Greater than 3rd Line Metastatic Pancreatic Cancer
Tara Seery, Arvind Shinde, Mira Kistler, Lennie Sender, Anand Annamalai, Omid Jafari Frank Jones, John H. Lee, Patrick Soon-Shiong
Nov 2018

Adoptive Cellular Therapy (ACT) With Allogeneic Activated Natural Killer (aNK) Cells in Patients With Advanced Merkel Cell Carcinoma (MCC): Preliminary Results of a Phase 2 Trial
Shailender Bhatia, Melissa Burgess, Hui Zhang, Tien Lee, Hans Klingemann, Patrick Soon-Shiong, Paul Nghiem, John M. Kirkwood

Development of an IL-2 independent NK cell line expressing high-affinity Fc-receptor to augmentmonoclonal antibody therapy Laurent Boissel, Kerry S. Campbell, Ashley M. James, Frances Toneguzzo, Hans Klingemann
Conkwest, Inc., Cardiff-by-the-Sea, CA USA; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA USA

A GMP-Grade IL-2 Independent NK Cell Line Expressing The High-affinity Fc-receptor (haNK) to Augment Antibody Therapeutics: Combination of haNK® With Anti-CD38 Monoclonal Antibody (Daratumumab) In Multiple Myeloma Boissel L, Klingemann H, Campbell K, Nichols K, Toneguzzo F, Khan J, Marcus, P, Williams BA, Keating A, and Soon-Shiong P, NantKwest, Inc., Cambridge, MA, USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Princess Margaret Cancer Centre, Toronto, ON, Canada; NantKwest, Inc., Culver City, CA, USA; University California Los Angeles, CA, USA

Targeted NK cells display potent activity against glioblastoma and induce protective antitumor immunity
Congcong Zhang, Michael C. Burger, Lukas Jennewein, Anja Waldmann, Michel Mittelbronn, Torsten Tonn, Joachim P. Steinbach, Winfried S. Wels
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany; Institute for Neurooncology, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, Frankfurt am Main, Germany; Edinger Institute, Goethe University, Frankfurt am Main, Germany; German Red Cross Blood Donation Service North-East, Dresden, Germany.

haNK, a cytotoxic human high affinity natural killer cell line, exerts enhanced ADCC mediated by avelumab (an anti-PD-L1 antibody) against multiple human tumor cell lines
Kwong Y. Tsang, Massimo Fantini, James W. Hodge, Rika Fujii, Ingrid Fernando, Caroline Jochems, Christopher R. Heery, James L. Gulley, Patrick Soon-Shiong, Jeffrey Schlom.
Laboratory of Tumor Immunology and Biology and Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; NantKwest, Culver City, CA.

Preclinical characterization of a novel monoclonal antibody targeting a neo-antigen expressed in ovarian and GI malignancies
Kristen Zeligs, Philip M. Arlen, Kwong Tsang, Lidia Hernandez, Massimo Fantini, Christina M. Annunziata.
Walter Reed National Military Medical Center, Bethesda, MD; Precision Biologics, Inc., Rockville, MD; National Cancer Institute, Bethesda, MD.

CD19 Target Activated Natural Killer (CD19.taNK) Cellular Therapy: A Novel immunotherapeutic Approach to the Treratment of Non-Hodkin Lymphoma (NHL)
Ravi Dashnamoorthy, Afshin Beheshti, Saheli Sarkar, Pooja Sabhachandani, Frank C. Passero Jr., Sneha Purvey, Laurent Boissel, Tania Konry and Andrew M Evens
Dec 2015

Novel Protocol Combining Metronomic Nant-Paclitaxel with HER2-Targeted Natural Killer Cells (innate Immunotherapy) for HER2 Positive Metastatic Breast Cancer
Shahrooz Rabizadeh, Barry Simon, Hans Klingemann, Deborah Sims, Raymond Weiss, Patrick Soon-Shiong
Dec 2015

NK-92: An “off the shelf” target-specific cytotoxic cell therapeutic
Boissel L, Campbell, KS. Toneguzzo F, Nichols K and Klingemann H poster)
Jun 2015

An “off the shelf,” GMP-grade, IL-2-independent NK cell line expressing the high-affinity Fc-receptor to augment antibody theapeutics
Laurent Boissel, Hans Klingemann, Kerry Campbell, Karen Nichols, Frances Toneguzzo, Paula Marcus, Brent Williams, Armand Keating, & Patrick Soon-Shiong
Apr 2016

Creating NK cell therapeutics with multiple targeting activities: Electroporation of mRNA for Chimeric Antigen Receptors (CARs) into human effecto cell lines
Junaid Khan, Laurent Boissel, Hans Klingemann, Frances Toneguzzo, Patrick Soon-Shiong
Oct 2016

Optimizing allogeneic natural killer cell reactivity by gene knock-out/knock-down of inhibitory receptors
Francisco Navarro
Oct 2016

Combination Therapy with Daratumumab and CAR-NK Targeting CS1 for Multiple Myeloma
Yibo Zhang, Lichao Chen, Yufeng Wang, Xinxin Li, Tiffany Hughes, Hans Klingemann, Don M. Benson and Jianhua Yu
Dec 2016

Intra-tumor injection of CAR-engineered NK cells induces tumor regression and protection against tumor re-challenge
Laurent Boissel, Hans Klingemann, Junaid Khan, Patrick Soon-Shiong
Oct 2016

Using unmodified & engineered Natural Killer cell lines in cancer treatment
Laurent Boissel
Oct 2016

Off the Shelf, Engineered Allogeneic Natural Killer Cell Therapeutics: aNK, haNK, taNK
Hans Klingemann
Sep 2016

Cytotherapy with targeted allogeneic NK cells
Hans Klingemann, Laurent Boissel
Aug 2017

Off the Shelf, Engineered Allogeneic Natural Killer Cell Therapeutics: aNK, haNK, taNK
Hans Klingemann
Feb 2017

CD19 Chimeric Antigen Receptor (CAR) Engineered Natural Killer (NK) Cell Therapy: Novel “Off the Shelf” Immunotherapy in CD20 Resistant Bcell NonHodgkin Lymphoma (NHL) Cell Lines and a Human Lymphoma
Xenograft Model
Sneha Purvey, Ravi Dashnamoorthy, Afshin Beheshti, Andreas Klein, Laurent Boissel,Saheli Sarkar, Tali Konry, and Andrew M Evens
Dec 2017